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Alternation learning impairments in R6/2 mice. R6/2 mice (n = 15) were impaired in T-maze alternation (A) but unimpaired in a simple T-maze black–white visual discrimination test (B), compared with controls (n = 13). Whereas control mice adopted spatial strategies, R6/2 mice used nonspatial strategies (C). Symbols indicate means ± SEM by mice of each group on each measure. Asterisksindicate significant differences between control and R6/2 mice (*p < 0.05; **p < 0.01).
