Fig. 3.

Effects of antidepressants on fluvoxamine-induced changes in the T80 parameter of 5-HT clearance. Electrochemical recordings were performed in the CA3 region of dorsal hippocampus of rats treated for 21 d with paroxetine (PRX; 5 or 10 mg), sertraline (SRTL), desipramine (DMI), phenelzine (PHEN), or vehicle (CTR). Fluvoxamine was pressure-ejected 60–90 sec before the second application of 5-HT. Barsand brackets represent mean ± SEM. The number of animals in each group is indicated at the bottom of each bar. *p < 0.01 comparison of each treatment group with control group, ANOVA, Newman–Keuls post hoccomparison.