Table 1.
Serum concentrations of the antidepressants
| Drug | Dose mg · kg−1 · d−1 | Serum level | |
|---|---|---|---|
| Steady-state (ng/ml) | Therapeutic (ng/ml) | ||
| Paroxetine (n = 7) | 10 | 411 ± 781-a | 5–100 |
| Paroxetine (n = 9) | 5 | 80 ± 22 | |
| Sertraline (n = 9) | 7.5 | 284 ± 96 | 30–150 |
| Desipramine (n = 5) | 15 | 348 ± 80 | 125–600 |
Serum concentrations of paroxetine (5 or 10 mg · kg · d), sertraline (7.5 mg · kg · d), or desipramine (15 mg · kg · d) were determined after 7–10 d of treatments by osmotic minipump, time at which steady-state should be achieved given the half-lives of these drugs in rats. The values obtained were compared to therapeutic drug level guidelines (Kaye et al., 1989).
F1-a
Mean ± SEM.