Table 2.
Effects of chronic antidepressant treatments on serotonin signal parameters
Treatment | Fluvoxamine | Amplitude (μm) | T80 (sec) | T40–80 (sec) | Time course (sec) |
---|---|---|---|---|---|
Control (n = 15)2-b | Pre | 0.80 ± 0.082-a | 106 ± 12 | 68 ± 9 | 241 ± 20 |
Post | 0.75 ± 0.06 | 141 ± 14* | 93 ± 10* | 376 ± 30* | |
Paroxetine (10 mg) (n = 8) | Pre | 0.78 ± 0.13 | 108 ± 9 | 68 ± 5 | 239 ± 11 |
Post | 0.70 ± 0.12 | 114 ± 10 | 73 ± 7 | 250 ± 15 | |
Paroxetine (5 mg) (n = 7) | Pre | 0.68 ± 0.12 | 103 ± 6 | 56 ± 4 | 184 ± 18 |
Post | 0.62 ± 0.10 | 114 ± 10 | 62 ± 4 | 218 ± 15 | |
Sertraline (n = 8) | Pre | 0.78 ± 0.10 | 67 ± 5 | 42 ± 3 | 155 ± 11 |
Post | 0.72 ± 0.09 | 72 ± 7 | 46 ± 4 | 165 ± 12 | |
Desipramine (n = 7) | Pre | 0.82 ± 0.10 | 111 ± 15 | 67 ± 8 | 228 ± 27 |
Post | 0.82 ± 0.10 | 136 ± 18* | 86 ± 10* | 316 ± 29* | |
Phenelzine (n = 6) | Pre | 0.58 ± 0.11 | 91 ± 8 | 60 ± 6 | 196 ± 11 |
Post | 0.62 ± 0.12 | 127 ± 10* | 89 ± 8* | 326 ± 15* |
Mean ± SEM.
Number of rats.
*p < 0.001, paired t test, comparing the effect of fluvoxamine on each parameter in each treatment group.