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. 1999 Dec 1;19(23):10494–10501. doi: 10.1523/JNEUROSCI.19-23-10494.1999

Table 2.

Effects of chronic antidepressant treatments on serotonin signal parameters

Treatment Fluvoxamine Amplitude (μm) T80 (sec) T40–80 (sec) Time course (sec)
Control (n = 15)2-b Pre 0.80  ± 0.082-a 106  ± 12 68  ± 9 241  ± 20
Post 0.75  ± 0.06 141  ± 14* 93  ± 10* 376  ± 30*
Paroxetine (10 mg) (n = 8) Pre 0.78  ± 0.13 108  ± 9 68  ± 5 239  ± 11
Post 0.70  ± 0.12 114  ± 10 73  ± 7 250  ± 15
Paroxetine (5 mg) (n = 7) Pre 0.68  ± 0.12 103  ± 6 56  ± 4 184  ± 18
Post 0.62  ± 0.10 114  ± 10 62  ± 4 218  ± 15
Sertraline (n = 8) Pre 0.78  ± 0.10 67  ± 5 42  ± 3 155  ± 11
Post 0.72  ± 0.09 72  ± 7 46  ± 4 165  ± 12
Desipramine (n = 7) Pre 0.82  ± 0.10 111  ± 15 67  ± 8 228  ± 27
Post 0.82  ± 0.10 136  ± 18* 86  ± 10* 316  ± 29*
Phenelzine (n = 6) Pre 0.58  ± 0.11 91  ± 8 60  ± 6 196  ± 11
Post 0.62  ± 0.12 127  ± 10* 89  ± 8* 326  ± 15*
F2-a

Mean ± SEM.

F2-b

Number of rats.

*p < 0.001, paired t test, comparing the effect of fluvoxamine on each parameter in each treatment group.

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