Table 2.

Effects of chronic antidepressant treatments on serotonin signal parameters

Treatment	Fluvoxamine	Amplitude (μm)	T80 (sec)	T40–80 (sec)	Time course (sec)
Control (n = 15)2-b	Pre	0.80  ± 0.082-a	106  ± 12	68  ± 9	241  ± 20
	Post	0.75  ± 0.06	141  ± 14*	93  ± 10*	376  ± 30*
Paroxetine (10 mg) (n = 8)	Pre	0.78  ± 0.13	108  ± 9	68  ± 5	239  ± 11
	Post	0.70  ± 0.12	114  ± 10	73  ± 7	250  ± 15
Paroxetine (5 mg) (n = 7)	Pre	0.68  ± 0.12	103  ± 6	56  ± 4	184  ± 18
	Post	0.62  ± 0.10	114  ± 10	62  ± 4	218  ± 15
Sertraline (n = 8)	Pre	0.78  ± 0.10	67  ± 5	42  ± 3	155  ± 11
	Post	0.72  ± 0.09	72  ± 7	46  ± 4	165  ± 12
Desipramine (n = 7)	Pre	0.82  ± 0.10	111  ± 15	67  ± 8	228  ± 27
	Post	0.82  ± 0.10	136  ± 18*	86  ± 10*	316  ± 29*
Phenelzine (n = 6)	Pre	0.58  ± 0.11	91  ± 8	60  ± 6	196  ± 11
	Post	0.62  ± 0.12	127  ± 10*	89  ± 8*	326  ± 15*

^F2-aMean ± SEM.

^F2-bNumber of rats.

*p < 0.001, paired t test, comparing the effect of fluvoxamine on each parameter in each treatment group.