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. 1999 Dec 1;19(23):10494–10501. doi: 10.1523/JNEUROSCI.19-23-10494.1999

Table 3.

Hippocampal content of 5-HT and 5-HIAA (ng/gm wet weight of tissue)

Treatment 5-HT 5-HIAA
Control (n = 10) 180  ± 83-a 191  ± 7
Paroxetine (10 mg) (n = 5) 199  ± 12 222  ± 11
Paroxetine (5 mg) (n = 6) 208  ± 17 188  ± 12
Sertraline (n = 4) 205  ± 14 210  ± 13
F3-a

Mean ± SEM.

Rats were chronically treated with paroxetine, sertraline, or vehicle. Hippocampi were processed for 5-HT and 5-HIAA content. Chronic treatment with SSRIs did not alter the content of serotonin or its metabolite in hippocampus.

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