Table 3.
Hippocampal content of 5-HT and 5-HIAA (ng/gm wet weight of tissue)
| Treatment | 5-HT | 5-HIAA |
|---|---|---|
| Control (n = 10) | 180 ± 83-a | 191 ± 7 |
| Paroxetine (10 mg) (n = 5) | 199 ± 12 | 222 ± 11 |
| Paroxetine (5 mg) (n = 6) | 208 ± 17 | 188 ± 12 |
| Sertraline (n = 4) | 205 ± 14 | 210 ± 13 |
F3-a
Mean ± SEM.
Rats were chronically treated with paroxetine, sertraline, or vehicle. Hippocampi were processed for 5-HT and 5-HIAA content. Chronic treatment with SSRIs did not alter the content of serotonin or its metabolite in hippocampus.