Fig. 6.

Effect on LTP is dependent on the time when endogenous BDNF is blocked by the antibodies. A, BDNF antibodies do not reduce LTP significantly when applied 10 min after TBS. B, Applications 30 or 60 min after TBS also do not affect LTP and its maintenance. Field EPSP slopes were plotted as percent of baseline. Bars indicate level of LTP at the end of each recording averaged over a 5 min period. Late phase LTP (3 hr after TBS) was measured for 30 and 60 min treatment groups (10 min group: BDNF Ab, n = 9 slices, 7 mice; control,n = 8 slices, 7 mice; 30 min group: BDNF Ab,n = 6 slices, 6 mice; control,n = 4 slices, 4 mice; 60 min group: BDNF Ab,n = 5 slices, 5 mice; control,n = 5 slices, 5 mice).