Fig. 12.
Receptor-induced modulation of calcium and inward rectifier potassium currents in purified somatotrophs.A, Effects of ET-1 and somatostatin on inward rectifier potassium current (Kir), recorded in perforated patch-clamp conditions, with 20 mmof extracellular potassium. B, Effects of ET-1 and somatostatin on voltage-gated calcium currents. The whole-cell recording conditions were used for these measurements (see Materials and Methods for the solutions that were used). Data shown onright panels are derived from six independent experiments.