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. 1999 Sep 15;19(18):7870–7880. doi: 10.1523/JNEUROSCI.19-18-07870.1999

Fig. 5.

Fig. 5.

C-deletion neuropilin-1 is a dominant negative receptor component for SEMA-3C but not for SEMA-3F. Sympathetic reaggregates were transfected with truncated Trk-B, full-length neuropilin-1, or C-deletion neuropilin-1 and treated with 10 c.u. of AP-SEMA-3C or 10 c.u. of AP-SEMA-3F. A, Growth cones expressing truncated Trk-B or full-length neuropilin-1 collapse when exposed to AP-SEMA-3C. Neurons expressing C-deletion neuropilin-1 do not respond to AP-SEMA-3C. B, Growth cones expressing truncated Trk-B or C-deletion neuropilin-1 collapse normally in response to AP-SEMA-3F. The SEM of four experiments is shown. **p ≤ 0.001 by Student’s two-tailedt test.