Conditions to induce the DME. A, Mean amplitudes of mEPSCs before and after the conditioning treatment with the solution lacking Ca2+ or containing either 10 μm CNQX or 1 mm MCPG.B, Mean amplitudes of mEPSCs before and after the conditioning treatment with 50 mm K+ and either 10 μm AMPA or 100 μm tACPD.C, The change of mEPSC amplitudes induced by the conditioning treatment with 50 mm K+, 10 μm AMPA, and 100 μm tACPD.