Skip to main content
. 1999 Sep 1;19(17):7289–7299. doi: 10.1523/JNEUROSCI.19-17-07289.1999

Fig. 1.

Fig. 1.

IVM potentiates P2X4 but not P2X2 or P2X3 channel currents.A, Representative recordings of currents mediated by P2X4 channels expressed in oocytes. Left trace, 100 μm ATP-evoked current before and after (right trace) addition of IVM (10 μm); IVM potentiates the amplitude as well as duration of the ATP-evoked current. B, Representative recordings for P2X2 channels expressed in oocytes. Left trace, 100 μm ATP-evoked current before and after (right trace) addition of IVM (10 μm); IVM causes no change in either the holding current or ATP-evoked current in P2X2-expressing cells. C, Summary of data from a number of cells (n > 5 for each) showing that IVM (10 μm) potentiates ATP-evoked currents at P2X4 channels but not at P2X2, P2X3, and P2X2/P2X3channels. D, Summary of data from a number of cells (n > 5 for each) showing that suramin (30 μm) can block ATP-evoked currents at P2X2, P2X3, and P2X2/P2X3 channels but not at P2X4 channels. Subsequent figures show a more pronounced potentiation of P2X4 channels at lower IVM and/or ATP concentrations. The data are derived from measurements of peak ATP-evoked currents.