Fig. 4.

Temperature change needed to produce a 20% inhibition in the fEPSP with the 32.5→38.5°C protocol. This cumulative histogram illustrates the temperature change required to produce a 20% decrease in fEPSP amplitude. Although a significant number of slices (12 of 58) exhibited this level of inhibition with a <2°C increase in the recording temperature, others (17 of 58) did not respond with such a decrease until the temperature had changed by >5°C. The cumulative histogram was approximately linear over this range, indicating that there was a nearly uniform distribution of thresholds across this range. The median temperature change required to elicit a 20% decrease in the fEPSP was 3.4°C.