Fig. 9.

BDNF mRNA and protein expression in NPG neurons, including the chemoafferent population. A, Photomicrograph showing localization of BDNF mRNA in a section through the E16.5 NPG complex. B, C, Photomicrographs of a double-labeled section showing colocalization of BDNF (B) and tyrosine hydroxylase (C) immunoreactivity in ganglion cells in the newborn PG. Arrows indicate a subset of the double-labeled cells. TH is a specific marker for PG neurons that innervate the carotid body, and virtually all TH-positive ganglion cells are also BDNF-positive. Scale bars, 100 μm.