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. 1999 Mar 15;19(6):2181–2186. doi: 10.1523/JNEUROSCI.19-06-02181.1999

Fig. 1.

Fig. 1.

A, Latency of onset ofPGE2-induced mechanical hyperalgesia in the hindpaw of the rat (n = 12).B, Time course ofPGE2-induced mechanical hyperalgesia (n = 12). C, Effect onPGE2-induced mechanical hyperalgesia (n = 22; p < 0.05) of the adenylyl cyclase inhibitors ddA and SQ22356 (SQ) when administered before [ddA/PGE2, n = 8; *p < 0.05;SQ/PGE2, n = 6; *p < 0.05; SC19220 (SC)/PGE2,n = 6; *p < 0.05] or 5 min after (PGE2/ddA,n = 10; p > 0.05;PGE2/SQ,n = 8; p > 0.05) intradermal administration of PGE2.D, Effect of PKA inhibitors [WIPTIDE andRpcAMPS (RpcAMP)] when administered before (WIPTIDE/PGE2,n = 10; *p < 0.05;RpcAMP/PGE2, n = 6; *p < 0.05) or 5 min after (PGE2/WIPTIDE,n = 10; *p < 0.05;PGE2/RpcAMP,n = 6; *p < 0.05) intradermal administration of PGE2. NS, Not significant.