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A, Time course ofPKACS (15 U; n = 12)-induced hyperalgesia is shown. B, Thirty minutes after intradermal injection of PKACS (n = 12) but not its vehicle (DMSO; n = 6), significant hyperalgesia (p < 0.05) is induced. WIPTIDE (WIP) injected before (WIP/PKACS, n = 6; *p < 0.05) or 5 min [PKACS/WIP (5′ post), n = 6; *p < 0.05], 6 hr [PKACS/WIP (6 hr post), n = 6; *p < 0.05] or 24 hr [PKACS/WIP(24 hr post), n = 6; *p < 0.05] after PKACS inhibitedPKACS-induced hyperalgesia.
