Fig. 2.

Relative scale of 8OHdG and 8OHG immunoreactivity with 1F7 antibody in prosubiculum neurons of 4 young controls, 10 presenile controls, and 13 senile controls, as defined in Materials and Methods, and in 22 cases of AD. Values shown are the means with SE. The difference among all controls and AD is significant by ANOVA (p < 0.0001), with post hocanalysis showing significant differences between young controls and AD (p = 0.0015), between presenile controls and AD (p = 0.0001), and between senile controls and AD (p = 0.0001).