Fig. 7.

Molecular structure of apNEP. A, Hydropathy analysis of apNEP. The 787 amino acid-long apNEP sequence was scanned using the computer program of Kyte and Doolittle (1982).Numbers on the horizontal axis refer to the amino acid sequence. Negative values correspond to hydrophilic regions and positive values to hydrophobic regions. The arrowheadindicates the only potential membrane-spanning segment of apNEP.B, Schematic representation of the primary sequences of the human and Aplysia NEP proteins. The cysteine residues in the two proteins are indicated by the one-letter codeC. The black rectangle represents the transmembrane region, and the thin rectangle represents the HEXXH gluzincin domain. The position of the possibleN-glycosylation sites is indicated by open lollipops.