Fig. 4.

PPI for male and female D4R mutant mice with vehicle control (0.9% saline; open bars) and AMPH (10 mg/kg; hatched bars). After AMPH treatment, both female wild-type (+/+) (A) and knock-out (−/−) (B) mice had significantly disrupted PPI (p < 0.01). In the male D4R mice, however, there was only a trend (p = 0.07) for AMPH treatment to disrupt PPI in wild-type (+/+) (C) and knock-out (−/−) (D) mice, with no significant interaction with genotype. Values represent mean ± SEM percentage of PPI for each prepulse intensity.