Fig. 3.

Heterologous overexpression of different Gα subunits failed to abolish the modulation of muscarine-sensitive K⁺ current (M-current) in SCG neurons.A, Superimposed current traces in the absence (○) or presence (●) of 10 μm muscarine recorded from neurons transiently expressing GFP alone (Control), Gα_s, Gα_oA, Gα₁₁, and Gα₁₂. The deactivation of M-current was evoked by a test pulse to −60 mV for 0.5 sec from a holding potential of −30 mV (inset). B, Summary of effects of different Gα subunits on M-current inhibition. Data are presented as mean ± SEM, and numbers in parentheses indicate the number of neurons tested. *p < 0.05 (by post hoc Dunnett’s test)