Fig. 4.
Heterologous overexpression of different Gα subunits significantly delayed Gpp(NH)p-mediated facilitation in SCG neurons. A, Representative Ca2+current traces showing time-dependent change of facilitation in control (left panel) and GαoA-injected (right panel) neurons. In both cases, 0.5 mm Gpp(NH)p was present in patch pipettes.B, time course of Gpp(NH)p-mediated facilitation in neurons expressing Gαs, GαoA, Gαi2, Gαz, Gαq, and Gα13. The dotted line in B indicates the absence of facilitation.