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I1495F enhances slow inactivation.A, Steady-state slow inactivation in hSkM1 WT (filled circles, n = 8) and I1495F (open circles, n = 8) after 50 sec conditioning pulse ranging from −130 to 10 mV. Band C show development of slow inactivation and recovery from slow inactivation, respectively, as a function of time for WT (filled circles, n = 7) and I1495F (open circles, n = 7) channels. Protocols are as described in Materials and Methods.
