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Pronounced synaptic fatigue in CA1 synapses during high-frequency stimulation in BDNF knockout mice. a, Examples of EPSPs elicited by a train of HFS (100 Hz) in hippocampal slices from CD1/BDNF mice. Note the significant synaptic fatigue in +/− and −/− mice. b, Summary of synaptic fatigue in CD1/BDNF mice. The slope of the 40th EPSP in the train is presented as the percentage of the first EPSP slope.n = number of recordings. c, Summary of synaptic fatigue in BL/6/BDNF mice.
