Table 1.
Morphological analysis of CA1 synapses in BDNF mutant mice
| DV/μm | L(μm) | DV | A(μm2) | ADV(μm2) | TDV | |
|---|---|---|---|---|---|---|
| CD1/BDNF | ||||||
| +/+ | 3.84 ± 0.11 | 0.86 ± 0.03 | 3.2 ± 0.12 | 0.58 | 0.07 | 9.3 |
| +/− | 2.49 ± 0.07* | 0.93 ± 0.02 | 2.2 ± 0.8* | 0.68 | 0.17 | 4.5 |
| −/− | 2.15 ± 0.06* | 0.92 ± 0.02 | 1.9 ± 0.7* | 0.66 | 0.22 | 3.4 |
| BL/6/BDNF | ||||||
| +/+ | 1.86 ± 0.12 | 0.71 ± 0.033 | 3.37 ± 0.21 | 0.39 | 0.04 | 10.3 |
| +/− | 1.40 ± 0.09* | 0.81 ± 0.032 | 2.40 ± 0.18* | 0.51 | 0.11 | 5.2 |
DV, Number of docked vesicles per active zone;L, active zone length (μm); DV/μm, number of docked vesicles per micrometer of active zone length,DV/μm = DV/L; A, total active zone area (μm2), A = 1/4 · π · L2; ADV, active zone area per docked vesicle, ADV = (L/DV)2; TDV, total number of docked vesicles per whole active zone, TDV =A/(0.866 · ADV). DV/μm,L, and DV are average numbers measured from 247–315 single sections of electron micrographs (mean ± SEM). Data from +/− and −/− were compared with those of +/+, and statistical differences were assessed by ANOVA test. *p< 0.005.