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. 1999 Jun 15;19(12):4867–4880. doi: 10.1523/JNEUROSCI.19-12-04867.1999

Fig. 3.

Fig. 3.

Human apoE3 and apoE4 in brains and CSF of transgenic mice. A, Western blot analysis showing apoE expression in whole-brain homogenates (n = 2 mice/genotype, 50 μg protein/lane) and CSF (14 μl/lane) from NSE-apoE3 and NSE-apoE4 mice. Human brain (occipital lobe) homogenate (50 μg protein/lane) and human apoE3 (5 ng/lane) standards are shown as controls. B, The apoE contents of brains and CSF were estimated by densitometric scanning of gels and by using human apoE standards. The apoE content in brains of transgenic mice was 4.4 ± 0.4 μg apoE/gm protein for NSE-apoE3 mice (n = 9), and 4.6 ± 0.5 μg apoE/gm protein for NSE-apoE4 mice (n = 13). The apoE content in the CSF of mice from both genotypes was 2.8 ng/μl (pooled from 6 mice/genotype).