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. 1999 May 15;19(10):4110–4122. doi: 10.1523/JNEUROSCI.19-10-04110.1999

Fig. 10.

Fig. 10.

Development of sensitization after 10 mg/kg cocaine in BDNF knock-out mice. Heterozygous BDNF knock-out animals showed a delay in the development of sensitization compared with wild-type littermate control animals. Data are expressed as the mean ± SEM number of photocell disruptions over the 30 min test period. BDNF knock-out animals (n = 5) showed a reduced amount of activity compared with littermate controls (n = 4) after the first 10 mg/kg cocaine injection (C1) but eventually became sensitized to cocaine. No differences between the groups were observed during baseline. Significant differences are shown for BDNF knock-out compared with wild-type littermate animals; F(1,7) = 5.70; *p < 0.05.