Fig. 5.

Effects of intra-NAc BDNF infusions on locomotor activation after 7.5 mg/kg cocaine. At 7.5 mg/kg cocaine, a near threshold sensitization dose, animals infused with BDNF showed a more rapid development of sensitization. Vehicle-infused animals also showed some evidence of sensitization. Cocaine injections (7.5 mg/kg) given on days 8 and 10 (after surgery) resulted in activity rates that were markedly increased in BDNF-infused compared with the vehicle-infused animals. Significant differences (*p < 0.05) at time points after cocaine injections were as follows: day 8 at 10, 20, and 30 min, F_(1,6) = 16.25, 12.01, and 10.67, respectively; day 10 at 10 and 20 min,F_(1,6) = 6.41 and 7.41, respectively. No differences between the groups were found before the cocaine injections. Data are expressed as the mean ± SEM number of photocell disruptions over the 30 min test period.