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. 1999 May 15;19(10):4110–4122. doi: 10.1523/JNEUROSCI.19-10-04110.1999

Fig. 9.

Fig. 9.

Long-term effects of intra-NAc BDNF infusions after saline or cocaine on responding for CR up to 5 weeks after cessation of BDNF administration. BDNF-infused animals showed enhanced responding for CR. After the first saline infusion (sal1), there were differences between the groups on the levers; CR lever responses were increased in the BDNF-infused compared with the vehicle-infused group (*p < 0.01). Similar effects were observed in sal2 in which there was a trend for a selective CR increase (F(1,6) = 5.44;p = 0.06). After subsequent saline (sal3–sal4) injections, only preferences for CR over the NCR lever were found. Responding on the CR lever was markedly increased and persisted in the BDNF-infused compared with the vehicle-infused animals after these cocaine challenges on days coc1, coc2 (F(1,6) = 19.81 and 13.01;p < 0.01), and coc4 (F(1,6) = 6.87; p < 0.05), and there was a trend on coc3. Significant differences are shown as **. No differences in responding on the NCR lever were observed. Note that the data for sal1 and coc1 are the same as depicted in Figure 8.