Fig. 8.

Potassium current response induced by PLA₂ is inhibited by 8-cpt-cAMP but not by TPA.A, Effect of 10 min perfusion with 0.1 mm8-cpt-cAMP (n = 6), 50 nm TPA (n = 3), and the corresponding controls 0.05% DMSO (n = 4) and 50 nm 4α-PMA (n = 3) on the potassium current response to PLA₂ (50 U/ml). Responses after perfusion (I) are normalized to responses before perfusion (I₀). *p < 0.01, significant difference from control; unpaired t test.B, Current responses to PLA₂ before and after perfusion with 8-cpt-cAMP and before and after perfusion with TPA, as indicated. Differences in response kinetics are caused by differences in duration of PLA₂ application and perfusion rate. 8-cpt-cAMP, TPA, and corresponding control solutions were applied by Y-tube.