Fig. 1.

AMPH-mediated DA release in AMPH- and saline-pretreated rats. Female Holtzman rats were pretreated with saline (triangles) or AMPH (squares) as described in Materials and Methods. DA release from the striatal slices was measured in response to AMPH (closed symbols) or KRB (open symbols) as described in Materials and Methods and reported as picomoles of DA per milligram wet weight (ww) ± SEM. Drugs given as a 2.5 min bolus at fraction 7 will reach the slices at fraction 9 (n = 3).A–A and S–A represent DA release from AMPH (A)- and saline (S)-pretreated rats after perfusion with 1 μm AMPH. A–KRB and S–KRBindicate basal DA levels from striatal slices from A- and S-pretreated rats. By the use of ANOVA to compare values for fraction 10, the peak DA responses differ (p < 0.0001). In post hocTukey–Kramer tests, S–KRB and A–KRBdiffer from S–A at p < 0.05 andA–A at p < 0.001.S–A differs from A–A atp < 0.001.