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Average number of Fos-immunopositive cells counted in nociceptive areas of the L4–5 spinal levels 1 hr after formalin injection in the ipsilateral hindpaw. Fos counts in rats injected with GBR-12935 in the RAIC (on-site) were significantly lower than those injected with vehicle or in brain areas surrounding the RAIC (off-site) (**p < 0.01). SDH, Superficial dorsal horn (i.e., lamina I and outer lamina II); NECK, neck of the dorsal horn (laminae IV–VI); CC, central canal area.
