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. 1999 May 15;19(10):4169–4179. doi: 10.1523/JNEUROSCI.19-10-04169.1999

Fig. 7.

Fig. 7.

Example showing depression of nociceptive responses of a single spinal WDR unit after microinjection of the dopamine reuptake inhibitor GBR 12935 into the RAIC. A, PSTH (bin width, 1 sec) of unit’s response to 50°C noxious heat stimuli, before (left PSTH) and 18 min after (middle PSTH) injection of GBR 12935 into RAIC.Right PSTH shows partial recovery of unit response 24 min after microinjection of the D1 receptor antagonist SCH-23390 at the same site in the RAIC. Inset shows representative sample of unit action potential. B, Graph plots responses of unit shown in A versus time relative to GBR 12935 (injected at first arrow). Time of injection of SCH-23390 is indicated by second arrow.Inset shows drawing of brain section containing RAIC injection site (dot). AC, Anterior commissure; Cd, caudate nucleus; RAIC, rostral agranular insular cortex.