Fig. 5.

Changes in AP and rCBF in anesthetized rats elicited by electrical stimulation of FN with or without excitotoxic lesions of the nucleus. rCBF was measured by laser-Doppler flowmetry; IBO or vehicle were microinjected 5 d earlier. A, Intact rat during and at end of electrical stimulation of FN (50 Hz; 1 sec on, 1 sec off stimulus current five times threshold). Note rapid rise in rCBF and AP, which recovers to baseline after 1 hr, characteristics of the fastigial pressor response. B, FN-lesioned rat. Note preservation of stimulation-evoked elevations in rCBF and AP, despite destruction of intrinsic neurons of FN as verified histologically.