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. 1999 May 15;19(10):4142–4154. doi: 10.1523/JNEUROSCI.19-10-04142.1999

Fig. 6.

Fig. 6.

Excitotoxic lesions of FN reduces the salvage produced by FN stimulation of both excitotoxic lesions and focal ischemic infarctions. Intrinsic FN neurons were destroyed by IBO 5 d before FN stimulation or sham stimulation. Average cross-sectional area (n = 5–6 per group; mean ± SEM; *p < 0.05, FN-stimulated compared with sham-stimulated) are plotted relative to distance from interaural line as in Figure 2. Groups of rats comprising sham-stimulated (filled triangles), FN-stimulated without excitotoxic lesions (open circles), and FN-stimulated (open squares) with excitotoxic lesions of FN were compared. A, Effects on excitotoxic lesions. IBO was microinjected into striatum 3 d after stimulating the FN, and rats were killed 24 hr thereafter. B, Volume of focal ischemic infarctions. Note that destruction of intrinsic lesions of FN abolish neuroprotection with either lesion.