Table 1.
Changes in mRNA levels across the hibernation cycle
| Immediate early genes | |
| c-fos | ↑AR (multiple brain regions) |
| c-jun | ↑AR (multiple brain regions) |
| junB | ↑AR (multiple brain regions) |
| junD | ←NSC→ (multiple brain regions) |
| NGFI-A | ↑AR (multiple brain regions) |
| Neuropeptides | |
| somatostatin | ←NSC→ (multiple brain regions) |
| enkephalin | ←NSC→ (multiple brain regions) |
| Prostaglandin D2 synthase | ↓H5 (hypothalamus) |
| Sleep deprivation cDNA 464 | ←NSC→ (multiple brain regions) |
| Glutamic acid decarboxylases | |
| GAD65 | ←NSC→ (hypothalamus) |
| GAD67 | ←NSC→ (hypothalamus) |
| Histidine decarboxylase | ←NSC→ (hypothalamus) |
| GAP 43 | ←NSC→ (cortex, hippocampus) |
| Control genes | |
| β-actin | ←NSC→ (multiple brain regions) |
| Cyclophillin | ←NSC→ (multiple brain regions) |
| Housekeeping genes reported to change in liver (Srere, 1995) | |
| F1-ATPase | ←NSC→ (cortex) |
| RNA poly(A) polymerase | ←NSC→ (multiple brain regions) |
| NADH-ubiquninone oxireductase | ←NSC→ (multiple brain regions) |
| 29 ddPCR probes | ←NSC→ (cortex) |
NSC, No significant change.