Table 6.
Frequency of collaterals formed along axons is not decreased by raising neurons in 7 nm taxol or 83 nm nocodazole
Treatment | Collaterals per 100 μm of axon (length in μm) | |||
---|---|---|---|---|
<10 | 11–20 | 20–30 | >30 | |
DMSO (6) | 1.60 ± 0.2 | 0.36 ± 0.1 | 0.10 ± 0.02 | 0.17 ± 0.03 |
Taxol (7 nm) (6) | 4.45 ± 0.66-a | 0.53 ± 0.1 | 0.11 ± 0.03 | 0.13 ± 0.03 |
Nocodazole (83 nm) (6) | 4.61 ± 0.66-a | 1.19 ± 0.2 | 0.30 ± 0.08 | 0.33 ± 0.10 |
Data were collected from six separate cultures from a total minimum of 100 neurons per treatment condition. Data was analyzed using an ANOVA with Bonferroni multiple comparison post hoc tests. Only axonal filopodia (<10 μm long) were found to differ between taxol- or nocodazole-treated neurons and DMSO controls. Mean + SEM is shown.
p < 0.001.