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. 1999 May 15;19(10):3773–3780. doi: 10.1523/JNEUROSCI.19-10-03773.1999

Fig. 5.

Fig. 5.

The C terminus of CB1 is also required for desensitization of GIRK activation in AtT20 cells. A, In AtT20 cells stably expressing rat CB1 receptors, 200 nm WIN 55,212-2 activates an inward current that rapidly desensitizes.B, In AtT20 cells stably expressing the CB1 truncation mutant ΔG418, 200 nm WIN 55,212-2 activates an inward current, but this current shows little desensitization.C, Aggregate data showing the rapid desensitization of inward current activated by WIN 55,212-2 in cells expressing rat CB1 (n = 5). D, Aggregate data showing no desensitization of the inward current activated by WIN 55,212-2 in cells expressing the CB1 truncation ΔG418 (n = 10).