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Effect of systemic administration of TFMPP on light-induced phase delays of the free-running activity rhythm. Data represent the mean ± SEM of six to seven animals per group (numbers shown on each bar). Light-induced phase shifts were significantly smaller in TFMPP-treated wild-type mice compared with that in vehicle-injected animals (p < 0.001), whereas TFMPP produced no inhibition of light-induced phase shifts in 5-HT1B receptor knock-out (KO) mice (p > 0.05).
