Fig. 6.

In utero cocaine exposure caused increased DAT binding sites in the fetal ventral midbrain. Pseudocolor autoradiograms show DAT binding site densities, labeled with the specific ligand [¹²⁵I]RTI-121 in matched sections through the rostral and caudal midbrain of a control (a, c) and cocaine-exposed (b,d) fetus. Each color represents a range of DAT binding densities (nanocuries per milligram) calculated from the calibrated ¹²⁵I standards exposed along with the brain sections. Analogous sections from each brain were determined using standard anatomical landmarks. Scale bar, 2 mm.