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Increased frequency of action potentials and membrane depolarizations caused by PF but not LMW Aβ. Whole-cell recordings in current-clamp mode were used to measure APs (single sharp deflections) and MDs (arrows). Baseline activities were recorded for 3–5 min (dotted lines). Addition of LMW Aβ (solid line) produced no significant increase in APs and MDs, whereas PF and fibrils (solid lines) increased the frequency of APs and the amplitude of MDs.
