Fig. 5.

Estrogen receptors were differentially modulated in ischemic injury. A, In injury, ERαmRNA was dramatically upregulated in the ipsilateral cortex of oil- and estradiol- treated rats, as compared with the contralateral cortex (†p < 0.001). The injury-induced upregulation ofERα gene expression was significantly higher than constitutive levels in both oil- (#p < 0.02) and estradiol-treated (#p < 0.01) rats.B, Estradiol prevented the injury-induced downregulation of ERβ mRNA in the ipsilateral cortex (*p < 0.01). In the absence of estradiol,ERβ expression in injury declined significantly below constitutive levels (#p < 0.01). Data (n = 7–11 per group) are graphed as a percentage of sham expression. These results were repeated four times, using two independent experimental groups. Data are represented as mean ± SE.