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Quantification of the effects of NMDA receptor antagonists on spreading depression. A, The amplitude of the peak response was only reduced significantly by 50 μmMK-801 (p < 0.01) but was not significantly affected by CGS-19755 (100 μm) or MK-801 (10 μm) (p > 0.05).B, The onset slope was reduced by both the competitive (CGS-19755) and noncompetitive (MK-801) NMDA receptor antagonists. Note that the scale in B is split to enable the display of both control and antagonist measurements.
