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. 1999 Aug 15;19(16):6795–6805. doi: 10.1523/JNEUROSCI.19-16-06795.1999

Fig. 5.

Fig. 5.

Field potential LTD is unimpaired by cannabinoid receptor activation in the absence of Mg2+.a, Bottom, Summary of field potential recordings in the presence of 5 μm WIN55,212-2. Data are expressed as normalized field EPSPs (± SEM). The initial slopes of fEPSPs were normalized to the baseline value preceding the induction of LTD. Testing stimuli were given every 20 sec. Mean values of LTD 25–35 min after low-frequency stimulation (LFS) were 1.01 ± 0.01 with Mg2+ present (n = 5) and 0.75 ± 0.03 after washout of Mg2+.Top, Sample traces showing fEPSPs recorded before LTD induction (left), after low-frequency stimulation delivered in the presence of normal concentrations of Mg2+ (middle), and after low-frequency stimulation delivered after washout of Mg2+ (right). b, Cumulative probability histogram of the magnitude of field potential LTD 25–35 min after low-frequency stimulation. Cumulative probability distributions are shown for control fEPSPs (0.78 ± 0.08;n = 6; solid gray), fEPSPs recorded in 5 μm WIN55,212-2 with Mg2+ present (1.01 ± 0.01; n = 7; dotted black), and fEPSPs recorded in 5 μm WIN55,212-2 after washout of Mg2+ (0.76 ± 0.04;n = 9; solid black).