Fig. 8.

LTP can be induced after adenosine receptor activation if magnesium blockade of NMDA receptors is experimentally relieved. a, Summary of field potential recordings in the presence of 10 μm CADO. Data are expressed as normalized field EPSPs (± SEM). The initial slopes of fEPSPs were normalized to the baseline value preceding the induction of LTP. Testing stimuli were given every 20 sec. Mean values of LTP 25–35 min after tetanus were 1.17 ± 0.05 with Mg²⁺present (n = 4) and 1.33 ± 0.10 after washout of Mg²⁺. b, Summary of whole-cell recordings in the presence of 10 μm CADO. Data are expressed as normalized EPSC amplitudes (± SEM). The amplitudes of EPSCs were normalized to the baseline value preceding the induction of LTP. Testing stimuli were given every 20 sec. Mean values of LTP 25–35 min after tetanus were 1.62 ± 0.25 (n = 5).