Fig. 4.

Effects of L-365,260 locally injected into the subiculum dorsal/CA1 of the hippocampus before the first trial (acquisition phase) (A) and before the second trial (retrieval phase) (B) of the two-trial memory task after a 2 hr time interval. L-365,260 was dissolved in cyclodextrin (0.5%). Control rats (C) received 0.5 μl/side of cyclodextrin (0.5%). The rats were tested 15 min after L-365,260 or cyclodextrin (0.5%) injection. Results are expressed as mean ± SEM of the percentage of time spent in the novel arm. *p < 0.05 versus control group; Dunnett’s test.