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. 1999 Aug 15;19(16):7230–7237. doi: 10.1523/JNEUROSCI.19-16-07230.1999

Fig. 5.

Fig. 5.

Microdialysis experiments in freely moving rats.A, Determination of the extracellular basal levels of CCK-LIR in the subiculum dorsal/CA1 of the hippocampus of rats (n = 5). The dialysis samples were collected each 30 min for 4 hr 30 min. Results are expressed as mean ± SEM of CCK-LIR in picograms per sample. There was no significant variation with time. B, Determination of the extracellular levels of CCK-LIR in the dorsal subiculum of the hippocampus during the two-trial memory task with a 2 hr time interval. Twelve of 14 rats spent more time in the novel arm compared with the 2 familiar ones (48 ± 4.2%). The microdialysis samples of these 12 rats were therefore analyzed. The first four samples were used to calculate the basal levels of CCK-LIR for each rat. Data were then calculated as percentage of the average of the extracellular basal levels before the test. Results are expressed as the mean ± SEM of the percentage of CCK-LIR in the sample versus basal levels. *p < 0.05; Dunnett’s test.