Table 5.

PTZ-induced seizure-related loci: univariate contingency table analysis of allele frequencies and seizure response in F2 generation mice

Marker	χ25-a	pValue5-b	Susceptibility allele	Mode5-c
D1Mit235	12.6	0.002	D2	A
D1Mit7	42.9	10−9	D2	D
D1Mit11	48.1	10−9	D2	A
D1Mit54	36.8	10−7	D2	A
D1Mit30	41.7	10−9	D2	A
D1Mit16	22.3	10−4	D2	A
D1Mit150	36.2	10−7	D2	A
D1Mit17	18.8	10−4	D2	A
D3Mit268	11.6	0.003	B6	D
D5Mit11	13.2	10−3	B6	R
D5Mit15	10.2	0.006	B6	R
D5Mit398	14.1	10−3	B6	R
D5Mit95	11.6	0.003	B6	R
D6Mit102	9.9	0.007	D2	D
D6Mit55	7.6	0.02	D2	D
D6Mit59	9.0	0.01	D2	D
D18Mit49	8.4	0.015	D2	D

^F5-aRepresents the association between genotype and seizure status based on the presence (n = 335) or absence (n = 176) of a PTZ-induced tonic-clonic seizure.

^F5-bOnly markers attaining a p < 0.02 threshold are shown.

^F5-cMode of inheritance was determined by best-fit regression analysis following marker recoding with seizure status as the dependent variable (D, dominant; R, recessive; A, additive).