Table 7.
Epistatic interactions between PTZ-induced seizure-related loci: multivariate stepwise logistic regression analysisa
| Marker7-b | Coeff ± SE7-c | Wald χ2 | pvalue7-d | Odds ratio7-e |
|---|---|---|---|---|
| D1Mit11 | 1.75 ± 0.37 | 22.1 | <0.0001 | 5.78 |
| D1Mit17 | −0.16 ± 0.65 | 0.06 | 0.81 | 0.85 |
| D3Mit268 | −0.30 ± 0.50 | 0.37 | 0.54 | 0.73 |
| D5Mit398 | −0.20 ± 0.63 | 0.11 | 0.74 | 0.81 |
| D6Mit102 | 0.91 ± 0.27 | 11.1 | 0.0009 | 2.48 |
| D1Mit17*D3Mit268 | 1.85 ± 0.79 | 5.56 | 0.018 | 6.39 |
| D3Mit268*D5Mit398 | 1.72 ± 0.76 | 5.10 | 0.024 | 5.56 |
F7-a
Regression was conducted with the dependent variable defined as the presence (n = 335) or absence (n = 176) of tonic-clonic seizure activity.
F7-b
Main effects (Table 5 markers) were fixed in this analysis. Marker data were recoded to reflect the best-fitting mode of inheritance. Results are expressed in terms of the seizure-susceptibility allele.
F7-c
Mean regression coefficient (±SEM) for the marker.
F7-d
Probability that the regression coefficient equals 0.00.
F7-e
Odds of expressing a PTZ-induced tonic-clonic seizure when possessing the susceptibility genotype at the indicated marker locus or loci.