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Extracellular l-NAME blocks Ca2+/CaM-induced synaptic potentiation (n = 10). Slices were pretreated withl-NAME (100 μm) for ≥1 hr before beginning postsynaptic injections of Ca2+/CaM. Five minutes after tetanus, slices were perfused with standard ACSF withoutl-NAME. A, Synaptic potentiation induced by postsynaptic Ca2+/CaM injections was blocked byl-NAME. B, Simultaneous field recordings showed that tetanus-induced synaptic potentiation was attenuated byl-NAME.
