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. 1999 Aug 15;19(16):6784–6794. doi: 10.1523/JNEUROSCI.19-16-06784.1999

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Copyright © 1999 Society for Neuroscience

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Fig. 5. — Extracellular applications of NO scavengers MGD-Fe and carboxy-PTIO block tetanus- but not Ca²⁺/CaM-induced synaptic potentiation.A,B, Slices were pretreated with MGD-Fe (150/75 μm) for 30–60 min before postsynaptic injections of Ca²⁺/CaM (n = 7). Five minutes after tetanus the medium was switched to standard ACSF.A, Synaptic potentiation induced by postsynaptic Ca²⁺/CaM injections was not blocked by MGD-Fe.B, MGD-Fe blocked tetanus-induced synaptic potentiation in field recordings. C, D, Slices were pretreated with carboxy-PTIO (30 μm) for 30–60 min before postsynaptic injections of Ca²⁺/CaM (n = 4). Three minutes after tetanus the medium was switched to standard ACSF.C, Synaptic potentiation induced by postsynaptic Ca²⁺/CaM injections was not blocked by carboxy-PTIO.D, Carboxy-PTIO blocked tetanus-induced synaptic potentiation in field recordings.