Fig. 7.

The neurotoxic action of the apoE peptide is attenuated by MK-801 or removal of extracellular calcium. Hippocampal cultures were exposed for 24 hr to saline (Cont), 2 μm apoE peptide (ApoE_p), 200 μm MK-801 (MK8) plus 2 μm apoE peptide, or medium lacking calcium plus 2 μm apoE peptide. The percentage of neurons surviving was quantified, and values are the mean and SEM of determinations made in four separate cultures. *p < 0.05 compared with values for cultures exposed to apoE peptide alone. **p < 0.01 compared with values in control cultures and cultures exposed to MK-801, and MK-801 + apoE peptide (ANOVA with Scheffe’s post hoc test).