Skip to main content
. 1999 Aug 15;19(16):7007–7024. doi: 10.1523/JNEUROSCI.19-16-07007.1999

Fig. 4.

Fig. 4.

Development of retinal projections to the dLGN in wild-type and MAOA-KO mice. Intraocular injections of HRP into wild-type C3H/HeJ (+/+) animals aged P3 (A,B) and P8 (E, F) and MAOA-KO animals aged P3 (C, D) and P8 (G, H). A,C, E, and G show the dLGN ipsilateral to the eye injected with HRP. B,D, F, and H show the dLGN contralateral to the eye injected with HRP. A,B, In wild-type mice at P3, retinal projections fill a large proportion of the ipsilateral dLGN (A) and the entire contralateral dLGN (B).C, D, Ipsilateral and contralateral retinal projections illustrated here in MAOA-KO mice at P3 are identical to those of wild-type mice. E,F, In wild-type mice at P8, ipsilateral projections are confined to the dorsomedial part of the dLGN (E), and the contralateral projection has withdrawn from this region (F): segregation of the two inputs appears complete in normal animals. G, H, In MAOA-KO mice at P8, fibers to the ipsilateral (G) and contralateral (H) thalamus still innervate overlapping territories: segregation has failed to occur. Scale bar, 110 μm.